Interestingly, both these pathways are required to regulate the dar phenotype in response to infection ([63] R. McMullan personal observation).
The observation that both domains of FUS-DDIT3 are required to regulate eIF4E expression provides the first molecular evidence that the FUS component of the fusion protein is required not only for transformation but also influences the phenotype of the tumor cells.
Previous studies suggested that during development both epithelial and mesenchymal signals are required to regulate cochlear progenitor proliferation and differentiation (Montcouquiol and Kelley, 2003; Doetzlhofer et al., 2004).
Moreover, in both subspecies, the kdpD/E two-component system required to regulate kdpABC expression is also non-functional.
Even though erythroid lineage commitment results in induction of both Bim and Noxa, only the former is required to regulate erythroblast expansion under homeostatic conditions [ 38].
The absence of PRMT1 or DHX36 blocked FLAG-Aven from stimulating translation, suggesting that both arginine methylation of Aven and DHX36 helicase activity are required to regulate the translation of mRNAs with G4 structures within their ORFs.
Milkey insisted that, under the Clean Air Act, the E.P.A. was required to regulate greenhouse gases in the same way that it regulated air pollutants, and its failure to do so was causing irreparable harm to Massachusetts.
Seven million Americans suffer from hyperhidrosis, or excessive sweating, in which people produce up to five times the amount of sweat required to regulate body temperature -- enough to derail a romantic dinner or wreck a business meeting.
In 2007, the US Supreme Court ruled that if it determined that carbon pollution poses a threat to public health or welfare, the EPA would be required to regulate emissions of that pollution under the Clean Air Act.
In 2007, the US Supreme Court ruled that the EPA was required to regulate greenhouse gases as pollutants, and in 2013, Obama announced the agency's intention to reduce power plant emissions.
