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Intracellular and extracellular S1P are both reported to trigger ER stress [ 25].
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Recently, metalloproteinase-cleaved CD95L was reported to trigger a motility-inducing signaling complex formation in triple-negative breast cancer cells.
Silicone has been reported to trigger a variety of inflammatory and immunological (both humoral and cellular) responses in humans [ 39- 42] and experimental animals [ 43].
It has even been reported to trigger the mini-strokes known as transient ischemic attacks.
Paradoxically, similar concentrations of TNF-α were reported to trigger apoptotic death of neural stem/progenitor cells20,35.
Although NPs have been reported to trigger PF development, its cellular and molecular mechanisms remain largely unclear.
ROS have been reported to trigger different pathological events due to oxidative stress including genotoxicity and fibrosis.
Chemokines such as MCP-1 has been reported to trigger integrin mediated firm adhesion and subsequent transmigration of monocytes [8].
Triggers for this disorder are among those commonly reported to trigger migraine, although headache is not reported in these patients.
Moreover, iASPP depletion was reported to trigger p73-dependent apoptosis in otherwise untreated cells.
Mitochondrial accumulation of p53 was reported to trigger waves of apoptosis, trancriptive dependent and independent [ 22].
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