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The indicated peak at 97C was greater than all permutation values and was observed in both replicates, as was the peak near the tip of the X-chromosome in the vicinity of yw.
The way we incorporated the reproducibility in our study was to consider only signals as relevant that reached a certain threshold in both replicates, as was the case in the analysis by Wade and colleagues.
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We initially sample the expression for all replicates using the same mean relative expression and variation between replicates as were observed in the Xu et al. data estimates.
A direct sample-to-sample comparison was performed for the RNAseq using the same experimental replicates as were used in the proteomics.
The results above were replicated, as is described in the supplemental materials.
Many of the interactions between SNPs and well-water As were replicated when urinary As was used as the exposure variable (see Supplemental Material, Table S5).
The HLA-A*02 association from the 2000 study was not replicated, as there was no significant difference in the carrier frequency compared to both control cohorts (0.50 versus 0.47 in DCI controls and 0.50 in NMDP controls) [ 4].
Branches recovered in greater than 50% bootstrap replicates are reported, as are Bremer support values.
The most significant peaks, which were overlapping in both replicates, were defined as binding sites.
Normalization of the expression data of both replicates have been done as described in [ 6, 77].
"X" indicates that the replicate was not considered as being successfully detected.
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