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The role of CD8 T cells in MS, an inflammatory demyelinating disease of CNS, has been enigmatic as it has been assigned both regulatory and pathogenic roles.
Do CD8+ T cells exhibit both regulatory and pathogenic activity as seen for different subsets of CD4+ T cells?
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Both regulatory and consumer pressure motivated this change.
In addition to truncation mutations, multiple genetic and epigenetic factors can contribute to DASE, and we propose that DASE is a functional index for cis-acting regulatory variants and pathogenic mutations, and that global analysis of DASE in breast cancer precursor tissues can be used to identify novel causative alleles for breast cancer susceptibility.
Enhanced innate immunity promoted by the environment may drive adaptive immunity by impairing regulatory and stimulating pathogenic T cell immunity.
One of these is the understanding that, in addition to conventional antibody dependent effects, B cells also play important regulatory and potentially pathogenic roles through antibody independent mechanisms, including antigen presentation, T cell activation and polarization, dendritic cell regulation, and cytokine and chemokine production [ 2].
Such phenomena can be observed in bacterial colonies, both commensal and pathogenic [43].
Any number of insults, both environmental and pathogenic, can lead to wasting.
Thus, NMB1646 is present in both commensal and pathogenic Neisseria.
Several reads matched both commensal and pathogenic organisms with equally strong identity percentages.
Professor Frick started by asking: what makes a bacterium pathogenic, since bacteria can have both commensal and pathogenic traits?
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