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Both proteins are implicated in the formation of stress fibers and suppression of neurite outgrowth and are ubiquitiously expressed, with an enrichment of ROCK-II in the central nervous system [17].
Both proteins are implicated in E2F1 regulation.
Both proteins are implicated in regulation of gene expression.
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While it remains to be determined whether efficient intracellular trafficking of LRP6 signalosomes requires LRRK2, it is intriguing to note that both LRRK proteins are implicated in endocytosis (33– 33).
The NF- κB/Rel family of proteins are implicated both in the activation of DC, and in the cellular response to radiation (Rescigno et al, 1999; Jung and Dritschilo, 2001).
Several proteins are implicated in both autophagy and endosomal receptor sorting, and numerous intersections between the endosomal and autophagic pathways have been described.
The PIAS proteins are implicated in apoptotic pathways, such as Smad, p53, and AR signaling.
Homer proteins are implicated in a variety of psychiatric disorders such as schizophrenia and addiction.
A few of the HPR genes that can be assigned putative functions, such as a series of novel Internal Proteins, are implicated in phage adaptation to the host.
Biologically, Vav1 plays a critical role in hematologic cell signaling, whereas Vav2/3 have a wider tissue distribution, but all 3 Vav proteins are implicated in cancer development.
LEA proteins are implicated in the mechanism of desiccation tolerance (Goyal et al. 2005).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com