Such an approach requires careful selection of protective components of C. abortus combined with an effective delivery system that elicits IFN-γ-producing CD4+ve memory T cells.
The identification of disease-promoting and protective components of the immune response to coinfection will inform future treatment strategies to combat this important public health burden.
Isoniazid blocks the synthesis of mycolic acids that are key protective components of the M. tuberculosis cell wall by inhibiting the essential fatty acid synthesis enzyme enoyl-acyl-carrier protein reductase, InhA (Fig 1).
In addition, our recent findings in normal human osteoblasts, in which proapoptotic and protective components of the Apo2L/TRAIL machinery appear to be coregulated in response to drugs such as ETP (Atkins et al, 2002), suggests that it is the balance of expression of these opposing influences that determines the outcome of exposure to Apo2L/TRAIL.
In an attempt to identify the protective component of A172, the CP from this strain (CP-A172) was purified and analyzed by gas liquid chromatography (GLC).
Phosphatidylcholine (PC) was found to be an essential protective component of colonic mucus (7, 8, 9).
p21, is an important protective component of the apoptotic pathway, regulating cellular arrest in the presence of DNA damage.
NLR represents a combination of two markers where neutrophils represent the active nonspecific inflammatory mediator initiating the first line of defense, whereas lymphocytes represent the regulatory or protective component of inflammation [ 30].
"Intestinal barrier" is a term that has been established more recently by gastroenterologists, immunologists and microbiologists to emphasize the protective component of the gut shielding us against bacterial invasion, or invasion of other microorganisms and their toxins.
Because ER stress is hallmarked by elevated levels of unfolded organelle proteins [ 27], CALNX has been suggested to be a key protective component of the unfolded protein response (UPR)/ER stress response, which activates protein folding/transport chaperones, while decreasing protein synthesis [ 28].
