Studies predominantly using bone marrow-derived MSCs have demonstrated that MSC-mediated immunomodulation is dependent on IFN-γ [ 43], and is largely mediated by factors such as indoleamine 2,3-dioxygenase or nitric oxide synthase, inhibiting both T- and B-cell proliferation and function [ 44].
KGF acts on both thymocytes and TECs, promoting their proliferation and function [ 30].
The proliferation and function (cytokine production) of both mitogen-stimulated (e.g., [18], [19] and antigen-stimulated [20]) T lymphocytes as well as antibody production by B lymphocytes [15], [19] are inhibited by 3-oxo-C12-HSL.
(7) Lowered heme availability selectively diminishes the proliferation and function of NSCLC cells.
Our studies demonstrated that G-CSF has critical roles in MDSCs migration, proliferation and function maintenance.
Adipocytes in bone marrow exhibit severe adverse effect on osteoblast differentiation, proliferation, and function.
Loss of ABCA1, and other cholesterol transport proteins, accelerates lesion formation and likely participates in myeloid cell proliferation and function.
Taken together, our findings provide evidence that G-CSF has critical roles in MDSCs migration, proliferation and function maintenance.
The interactions between cells and an underlying biomaterial are important for the promotion of cell adhesion, proliferation, and function.
Cell viability, proliferation and function were assessed to understand the application of cell patch transfer to bone substitute.
