Both proliferation and Hes5 expression has been shown to be regulated by Notch activity (Ohtsuka et al., 1999; Basak and Taylor, 2007).
Highly hypoxic tumour cells are characterised by poor proliferation (Sullivan and Graham, 2007; Jubb et al, 2010; Wilson and Hay, 2011); therefore, cells exhibiting both proliferation and EMH expression could represent cells exposed to additional proliferative stimuli or alternative regulation of EHM and not necessarily diminished oxygen availability.
Moreover, overnight treatment of hippocampal precursors with exogenous FGF2 (Ciccolini and Svendsen, 1998; Lillien and Raphael, 2000; Santa-Olalla and Covarrubias, 1999) increased EGFR expression in mutant cultures to wild-type levels (Fig. 3G), showing that, in the absence of exogenous EGF, FGF2 can rescue both proliferation and EGFR expression in mutant precursors.
Embedding of SMC in 3D collagen matrices caused a marked decrease in both cell proliferation and expression of SMA.
Interestingly, imatinib appears to target specifically mesenchymal progenitors by inhibiting both their proliferation and expression of fibrosis markers in vitro [ 98].
9 out of these 10 subjects showed elevated suppression of both proliferation and IFN-gamma expression compared to controls, indicating good concordance between the two suppression assays (Table 1).
Additionally, both proliferation and β-actin expression were significantly higher for cells grown on flat PCL/HAp films than on any of the textured ones, serving as an evidence for the stressful effect of topographic features on the cell growth when the dimensions of the two are in the same range, as it happened to be inherent in the design of this study.
Furthermore the paucity of both proliferation and B-cell gene expression is indicative of a relatively low representation of neoplastic B cells.
Therefore, PML/RAR α might disrupt both proliferation and differentiation by repressing CDKN2D expression, thus promoting the pathogenesis of APL.
T helper and T cytotoxic primary proliferation and expression of activation and migration markers was observed both in draining and distal sites.
