Sentence examples for both primary and distant from inspiring English sources

It is worth noting that some tumors showed the same heterogeneous pattern in both primary and distant locations with adjacent positive and negative areas, detected by both IHC and FISH methods.

In comparison to conventional antigen immunization strategy, that is, priming with OVA plus complete Freund's adjuvant (CFA) and boosting with OVA plus IFA, prime immunization with HCuSNPs-CpG plus laser produced stronger anticancer effects against both primary and distant tumors.

87 In an animal model of prostate cancer, tumor cryotherapy with simultaneous anti-CTLA-4 immunotherapy produced enhanced immune-mediated protection against tumor rechallenge at both primary and distant tumor sites.

Average microvessel count and BVI include many steps that are necessary for haematogenous dissemination, that is, they are the results of tumour invasion to extracelluar matrices and basement membranes, entering the circulatory system, and activating angiogenesis at both the primary and distant sites.

Compared to clinical profiling studies, animal models of metastasis have several critical advantages, which stem largely from the ability to isolate and characterize both primary tumors and distant metastatic lesions, and to manipulate the expression levels of one to several genes at a time to directly test their roles in disease progression.

Host defense peptides, which selectively target differences between cancer and non-cancer cell membranes, have excellent tumor tissue penetration and can thus reach the site of both primary tumor and distant metastasis.

New methods are needed to allow for non-invasive or minimally invasive evaluation of HER2 expression in vivo that can be repeated in individual patients and can provide an assessment of global HER2 expression in both primary tumors and distant metastasis.

Of the 206 patients from whom both primary tumor and distant metastatic samples were available, there was concordance between primary tumor and metastases in 197 samples (95.6%; 179 negative and 18 positive).

4-Methylumbelliferone is a promising therapeutic agent targeting both primary tumours and distant metastasis of osteosarcoma, possibly via suppression of HA retention.

In stage IV disease, a curative strategy can only be proposed for selected patients when the primary and distant metastases are both resectable with 20-50% rates of long-term survival and cure after complete resection [ 1].

Similarly, bone marrow-derived myeloid cells can promote tumour growth at primary and distant sites (Weilbaecher et al, 2011).