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RREB1 and SRF were also both predicted to interact with the same factor, MEF2 [ 43].
As expected, pairs of genes predicted to interact both positively and negatively tend to share GO Process and SGD Phenotype annotations (Table 3), confirming that these genes generally operate within similar biological processes in the cell.
Similar effects were also seen in mutants P378A, A430S, and Y431A, respectively, although P378 was predicted to interact with both types H and A oligosaccharides, while A430 and Y431 do not appear to interact with either of the two oligosaccharides [13], [15].
The two partial agonists are not predicted to interact with both Ser2035.42 and Ser2075.46 in TM5, perhaps leading to only partial agonism.
Members of both clades within this superfamily are predicted to interact with ligands in a similar spatial location, with their specific inserts playing a role in the process.
Proteins that were predicted to interact with both S. pombe Tor kinases are involved in cell shape determination; cortical patch localization and cell polarity; septum formation; vacuole targeting and sorting; endocytosis; and autophagy.
The adamantyl motif is predicted to interact with the protein through hydrophobic interactions with Tyr 177 and Leu 217.
Figure 5 Compounds predicted to interact with DHFR by the target prediction algorithm, and predicted by the PCM model to have a pIC50 value higher than 7 pIC50 units.
The remaining 159 targets were all predicted to interact strongly only with desmopressin; for five of those interactions there was experimental validation in ChEMBL.
The same is true of residues predicted to interact with CAR directly, such as Lys-417 (number is for HAdV-C5K).
