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There was no evidence of publication bias by Egger's test for both pooled effects of all outcomes from direct comparison.
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Given that most candidate polymorphisms available in ARCTIC failed to demonstrate nominal statistical significance individually, an aggregate model was constructed to explore pooled effects of increasing numbers of variant alleles.
Pooled effects of 17 studies showed that nasal decolonization had a significantly protective effect against surgical site infections associated with Staphylococcus aureus (pooled relative risk 0.39, 95% confidence interval 0.31 to 0.50) when all patients underwent decolonization (0.40, 0.29 to 0.55) and when only S aureus carriers underwent decolonization (0.36, 0.22 to 0.57).
Pooled effects of 15 prophylaxis studies showed that glycopeptide prophylaxis was significantly protective against surgical site infections related to methicillin (meticillin) resistant S aureus (MRSA) compared with prophylaxis using β lactam antibiotics (0.40, 0.20 to 0.80), and a non-significant risk factor for methicillin susceptible S aureus infections (1.47, 0.91 to 2.38).
The final measure considered is the average " variance" of the predicted pooled effects.
First, both the central strength and limitation of our study is that we pooled effect estimates of the included studies.
Across all three soft policy measures we found a statistically significant random-effects pooled effect size of 0.15.
Combining results across 60 studies that employ causal research designs, we find pooled effect sizes of 0.49 standard deviations (SD) on instruction and 0.18 SD on achievement.
Pooled effect sizes for each of the main comparison groups are presented in table 3.
We obtained the combined results of 2 228 850 SNPs, pooling effect sizes by means of a fixed effects inverse variance meta-analysis as implemented in METAL.
We pooled the effects of zinc lozenges for each symptom and calculated point estimates and 95% confidence intervals (95% CI).
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