Sentence examples for both plasma and brain from inspiring English sources

Subsequent evaluation of two new compounds in pharmacokinetic studies using intraperitoneal dosing in rats demonstrated good exposure in both plasma and brain samples.

The methanol extract of the Seppak column, expected to contain parent [11C]prucalopride, contained no parent compound for both plasma and brain extracts taken at 5 and 30 min post injection.

Both plasma and brain samples were analyzed using LC/MS/MS determination, according to ADME-Bioanalysis (Vergeze, France) procedures.

Both WT and R6/2 mice treated with minocycline weeks had detectable concentrations of the compound in both plasma and brain.

However, there were no significant differences among the different groups, for both plasma and brain.

Quinidine kinetics in both plasma and brain were analyzed using mixed effects modeling in NONMEM.

These findings suggest that the potency of the anxiolytic effect is dependent on both the plasma and brain concentration.

Both the plasma and brain profiles were best described with two compartment models.

If total compound were responsible for efficacy in both tissue compartments, one would expect to see similar decreases in Aβ42 and Aβ38 in both the plasma and brain in the Tg2576, as the exposure in each compartment is similar.

AGSMs were shown to be potent and efficacious in vivo in decreasing the levels of Aβ42 and Aβ40 in both the plasma and brain of APP transgenic mice, and chronic efficacy studies revealed that AGSMs dramatically attenuated AD-like pathology in the Tg2576 APP transgenic mouse model.

After oral application, CD-1 mice showed significant levels of both compounds in plasma and brain (Table 1).