In contrast, the other extensively investigated typhoid agent, S. paratyphi A, at both physical map and sequence levels, has a uniform genome structure among different isolates, even though this organism does have insertions totaling 100 kb clustered together on the genome.
For the discovery of general principles for identifying human disease genes, and enabling their application to medicine through the creation and analysis of genetic, physical and sequence maps of the human genome 8 Charles L Sawyers Chair, human oncology and pathogenesis programme at Memorial Sloan-Kettering Cancer Centre.
A single rice species may support multiple genetic, physical, and sequence maps, gene annotations, and genome assemblies.
Comparison of genetic, physical and sequence maps allows researchers to fill in gaps and extend knowledge both within and across species.
Genome maps (genetic, physical, and sequence) may not provide immediate biological insights, but they pave the way for future discoveries.
A Graph-Theoretic Approach to Comparing and Integrating Genetic, Physical and Sequence-Based Maps.
Physical and sequencing gaps were closed using a combination of primer walking, generation and sequencing of transposon-tagged libraries of large-insert clones, and multiplex PCR [38].
The contig-based SSR markers can anchor corresponding contigs onto a genetic map and further establish direct links between genetic, physical, and sequence-based maps [ 25, 29, 30].
Linkage mapping permits the location of genes controlling traits of importance to chromosomes through their association with molecular markers and thus, represents a powerful tool for the positional cloning of major genes, the characterisation of quantitative trait loci (QTL), and the anchoring and ordering of contigs and scaffolds of both physical maps and genome sequence assemblies.
11 According to Hauer and Oster, 12 testing of physical function assumes that test participants are able to (1) comprehend the test commands, (2) develop an adequate physical action and sequence and (3) remember both during execution of the test.
