Sentence examples for both periphery and brain from inspiring English sources

Finally, accumulating molecular, transcriptomic, proteomic and metabolomic approaches as well as biochemical data points to abnormalities in mitochondria in both periphery and brain in schizophrenia [19] [28].

We next compared the kinetics of inflammatory mediator production in both the periphery and brain (Fig. 3).

5-HTP is regarded as a precursor of 5-HT, and 5-HTP cells are essentially thought to shunt 5-HT production in 5-HT-producing cells (5-HT cells), in both the periphery and brain.

The idea of BBB came from variance of dye absorption between periphery and brain [ 20].

There are concomitant decreases in inhibitory phosphorylation of GSK3β in the periphery and brain post-mortem tissue.

This different pattern of interaction is also reflected by different time courses of cytokine induction in the periphery and brain.

The BBB collaborates with the periphery and brain parenchyma in order to eliminate Aβ from the brain through several sophisticated mechanisms.

Analysis of the potential mechanisms led us to conclude that the aggravation of sickness is associated with enhanced production of proinflammatory cytokines in the periphery and brain, increased kynurenine formation and activation of immune responsive brain nuclei.

Tissue concentrations of R- and S-flurbiprofen in the periphery and brain (Fig  12C) were about 5,000 to 10,000-fold lower than plasma concentrations, which is in agreement with high plasma protein binding.

Interestingly, Menetrey et al. (1980) reported that a large proportion (40%) of LSN neurones project bilaterally to supraspinal structures, including the PAG, and they suggested that the LSN might represent a relay in unmyelinated pathways between the periphery and brain.

Thus, the effects of NOD agonists to prime the production of proinflammatory cytokines in response to LPS exhibit different patterns of interaction in the periphery and brain, depending on the compounds investigated.