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In the vehicle control group, rears against the cylinder wall with both paws were most frequent (67.2 ± 4.0%).
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In the cylinder test, the use of both paws was most common in the MPTP-lesioned control group (77.9 ± 5.4%), whereas a treatment with 30 mg/kg fasudil (49.0 ± 4.1%) or 100 mg/kg fasudil (59.2 ± 4.8%) reduced this behaviour in spite of the MPTP lesion.
Pain signaling, evoked by noxious heat to cutaneous receptive field of the paw were most likely transduced by TRPV1 expressing nociceptive neurons but occurrence of other heat sensors, such as TRPV2, the super heat receptor, could not be rule out.
Both paws were measured and mean thickness for each animal was calculated.
Both paws were measured and the mean used as a composite score for each mouse.
The frequency of simultaneous use of both paws was lowest in pugs (P < 0.0001).
The new activation foci located in representations of anterior vibrissae, front paw and hind paw were specific for the vibrissae stimulation and were most probably a new functional representation of the vibrissae.
As paw edema was most prominent on the hind-paws; only the joints in the hind-paws were assessed analytically using Tukey's post hoc test.
These changes were most robust after stimulation of the inflamed paw although similar findings were seen on the non-inflamed paw and tail.
Paw swelling was most severe (upto 3.0 mm) in the CIA-induced control group, at day 30.
Dumas wrote that in ancient times, frontal bear paws were considered the most delicate part of the animal, that rich Germans highly valued bear cub flesh and that bear ham had become a refined but easily accessible dish on European tables.
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