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Between the two pathways, there will be more observed synthetic-lethality interactions: if corresponding components are deleted or suppressed in both pathways at once, the fault-tolerance of the system is defeated and the strain dies.
Similar(59)
Many downstream signaling effectors involved in malignancy are regulated by both Stat3 and NF-κB, such that targeting both of these signaling pathways at once by combining ATRA + AUR, may produce a synergistic tumor suppressive effect.
In 2014, Samson, Nagel, and colleagues devised a new technique that allows them to rapidly measure four different DNA repair pathways at once.
In theory, such an approach may abrogate or delay resistance by disrupting multiple pathways at once.
Furthermore, it achieves a new level of complexity by considering multiple pathways at once in a comprehensive manner.
In contrast to the traditional single molecule-single target approach, being able to target two or more pathways at once or a few players in the same pathway would be a more effective therapy for the treatment of cancer.
Static modeling of dynamic interactions aggregates several different pathways at once, which leads to missing key factors that are only active at specific times during response (Ernst et al., 2007).
Medupe is tackling both these problems at once.
Both smiled at once.
It can play both ways at once.
Both are at once right and guilty.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com