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Investigations of both pathway activation and blockade of signal transduction are necessary for the determination of pathway-specific effects, and the readouts should focus on all pathways relevant for normal lung development and lung injury to get a comprehensive view on BPD.
In muscle, both pathway and gene-set enrichment analyses show effects of UAG treatment on gene clusters involving adipogenesis.
Further, we explored the interactions and crosstalk between SZ-enriched pathways by taking advantage of both pathway and interaction network data used in this study.
Finally, chemotherapy sensitivity patterns were assessed across groups of patients defined by both pathway clusters and age (≤45 years and ≥65 years).
As highlighted in Figure 5 – one can find enrichments that are supported by both pathway databases, while other enrichments are highlighted in the analysis using one or the other pathway database.
We defined both pathway maps as "autonomous pathway maps".
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Both pathways offer advantages and disadvantages — but in both, incentives and capacity will dictate success or failure.
Both pathways converge to activate the pivotal protein of the complement system, called C3.
All tested agonists showed (almost) full agonism in both pathways.
Many studies considered both pathways, especially above 848 K (575 °C).
However, during TKI treatment, both pathways are inhibited.
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