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Detection of both pathologies in both disorders would have strengthened a coincidence without causality or a common genetic basis for these paroxysmal disorders and vascular anomalies.
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Moreover, studies in depression suggests functional, cellular and molecular pathologies in both areas [7] [10].
Thus, MgC-GEP should be a potentially powerful tool for multigene expression profiling in different tissues, during development, or during specific pathologies in both basic and pharmaceutical research.
The prompt calving assistance provided enabled a significantly lower incidence of both puerperal and neonatal pathologies in both the HMO and MMO groups (Table 2).
Given the prior observed related pathology in both diseases, we hypothesized, that molecular mimicry may explain the pathology seen in both diseases too.
In this regard, the phenotypic concordance of Aβ lens pathology in both diseases, DS and AD, is striking.
As mentioned above, disturbances in the hypothalamic-pituitary-adrenal axis could contribute to weight loss and there is marked adrenal pathology in both the R6/2 and HdhQ150/Q150 mice.
Moreover, these findings confirm increased Aβ accumulation as a key pathogenic determinant linking lens and brain pathology in both DS and AD.
Pathology in both strains consisted of moderate to severe parenchymal damage in the cortex, hippocampus, striatum and corpus collosum.
Dysregulated inflammatory response may also represent a common mechanism by which microglial impairment contributes to pathology in both diseases.
MRI primarily images protons in fat and water and can depict anatomy and pathology in both soft tissue and bone in great detail.
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