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Expression of integrin subunit α6 has been linked to the acquisition of migratory potential in a wide variety of cell types in both pathological and physiological capacities.
The vascular phenotype in both pathological and physiological angiogenesis may therefore depend on the balance of VEGF isoforms.
Growth factors have been demonstrated to regulate the production of hyaluronan through the modulation of hyaluronan metabolic enzymes expressions under both pathological and physiological conditions [ 88].
Hypermutated nuDNA with hundreds of mutations per kilobase can be found in both pathological and physiological settings (Suspène et al, 2011a).
Enhanced oxidative stress has been found to play a crucial role in the induction of apoptosis under both pathological and physiological conditions.
Availability: The server is available at www.biocomputing.it/picmi Contact: [email protected] The availability of novel high-throughput technologies for identifying variations, both pathological and physiological, in sequenced genomes is producing a wealth of data that is readily available to researchers.
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Thus, evidence suggests that both pathological – and physiological-induced changes in mammary stroma contribute to breast cancer progression.
In previous reports, we have unravelled the promigratory/invasive molecular underpinnings of CD95 signalling both in pathological and physiological scenarios.
There is accumulating evidence of the biological significance of LCRs both in physiological and in pathological situations.
Apoptotic activity is essential for organ homeostasis by keeping under control cell number and tissue tropism both in physiological and pathological circumstances [4,6].
However, TGF-β may induce entirely different cellular responses, depending on the cell type and stimulation context, both under physiological and pathological conditions [ 29, 31].
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