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The increase of these both parameters of bone formation resulted in a highly significant increase of bone formation rate in 1,25(OH 2D3-treated rats in cOH 2D3-treatedoth vehicle-tratsed Ain and healthy animals (p < 0.001, Figure 4comparison
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Bone histomorphometry showed that both doxycycline and zoledronate significantly increased several parameters of bone formation in the femora, including osteoid volume (data not shown), osteoid surface and the number of osteoblasts per bone surface (see Table 1, Figure 2B and D).
In this study, we evaluated the bone mineral density as well as the histomorphometric parameters of bone formation and bone mass in both F508del-Cftr homozygous mice (F508del Cftrtm1Eur) and Cftr+/+ littermate controls at 6 (prepubertal), 10 (pubertal), and 14 (young adult) weeks of age in both sexes.
The evaluation of BMD by DEXA or ultrasound or both should be coupled to an endocrinological evaluation (hormones, vitamins and parameters of bone turnover).
The bone architecture of F508del Cftrtm1Eur and wild-type (WT) littermate mice was evaluated by bone densitometry, microcomputed tomography, and analysis of the dynamic parameters of bone formation.
PFTBA supplementation significantly increased structural parameters of bone in radial bone defects and triggered a significant 1.4-fold increase in bone volume in the spinal fusion model.
For this reason there has been increasing interest in studying architectural parameters of bone, beyond bone density, which may affect bone strength.
One advantage of PET over conventional BS is that 18F-fluoride SUV correlates well with kinetic parameters of bone formation [5].
However, bone strength and fracture risk are also influenced by parameters of bone quality such as micro-architecture and tissue properties.
This investigation of microstructure in the human proximal femur probes the relationship between the parameters of the FRAX index of fracture risk and the parameters of bone microstructure.
Secondary aims are to understand whether vitamin D3 supplementation improves parameters of bone microarchitecture, balance, physical function and quality of life.
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