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This design differs from both parallel and cross-over designs.
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For example, the precision on V and ka was improved by the inclusion of densely sampled patients compared to a study design consisting of solely sparsely sampled patients in both the parallel and cross-over settings (Table II).
Randomised blinded placebo-controlled parallel and cross-over groups design.
The blood/plasma sampling protocols (sparse and dense) were identical for the parallel and cross-over study designs in the hypothetical drug example (Table I).
The methodological quality of eligible randomized trials (parallel and cross over designs) was evaluated with the Cochrane risk of bias assessment tool.
A similar number of trials used parallel (24 trials (53.3%)) and cross-over (21 trials (46.7%)) designs.
Through parallel analyses of different data types and cross-over mixed analyses, we found shifting patterns in motivations across question type, question topic and question timing.
We conducted both "parallel" analysis (independent analysis of the two types of data) and "cross-over mixed analysis" [ 47] (transformation of free text generated by open-ended questions into numeric variables, enabling integration with, and comparison to, quantified responses from the close-ended questions).
The highway run parallel to, and crosses over, the St.
The following designs will be included randomised controlled trials (cluster and parallel design); cross-over trial; case series or case controls; one-arm trial; non-randomised trials; cross-sectional or cohort studies and case reports.
CCT accounted for about 5% of all submissions, and comprised all clinical trials where a controlled parallel or cross-over design was used.
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