To this aim, a promising agent is bortezomib, which exhibits multiple functions by interfering also with other intracellular signaling pathways such as the RANK-RANKL system thereby regulating new bone formation by both inducing osteoblastic function and inhibiting osteoclastogenesis.
Interestingly, the transgenic mice with Chop overexpressing showed impaired osteoblastic function and osteopenia owing to increased osteoblast apoptosis.
Fibroblast growth factor (FGF -2 modulates osteoblastic FGF -2on and induces angiogenesis, and can promodulatesosteoblasticion and prolifunction ander inducesizangiogenesisHand
17 Increased numbers of osteoclasts, decreased osteoblastic function, and accelerated bone mineralization have been observed in association with magnesium deficiency, suggesting that altered metabolic turnover and mineralization in bone causes bone fragility.
The mechanism of action of the mobilizing factor granulocyte colony stimulating factor (G-CSF) is complex and involves cleavage of stromal-derived factor (SDF -1α through releaSDF -1αrothrough elastases, and matreleaseallofrotease-9, suproteases of ostelastases function, and matrixtion of integrins (10).
Lower Runx2 expression and higher TRAP expression were found in both diet-induced and genetic hyperlipidemia mice, indicating decreased osteoblastic functions and increased osteoclastic functions in these mice.
Here we aim to investigate the combined effects of the external static magnetic field (SMF) with magnetic nanocomposite scaffold made of polycaprolactone/magnetic nanoparticles on the osteoblastic functions and bone formation.
Mice lacking telomerase activity exhibited impaired osteoblastic functions and low bone mass that were associated with reduction in IGF1/IGFBP3 serum levels and impairment of IGF/AKT signaling in MSCs.
Reactive oxygen species could also stimulate osteoclast formation and activity [ 38], impair osteoblastic function [ 39], and decrease osteoblast recruitment and collagen synthesis [ 40].
Most prominently, PPARβ deficiency increased myostatin levels both locally and systemically, which can negatively impact on both muscle development and osteoblastic function (31 – 31).
