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Thus, the observed crystallographic interfaces of APOBEC3G may be important for both oligomerization and function.
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Cav3 is known to be natively palmitoylated at three positions within its C-terminal domain (C106, C116, and C129), modifications that likely impact Cav3 lipid membrane interactions, oligomerization, and function (reviewed in ref (2)).
These data indicate that cosolubilization of NDSBs effectively relieves both oligomerization and aggregation by shifting the equilibrium toward the monomers.
Cleavage of 1, 5, and 11 residues showed diverse effects on oligomerization and chaperone function [17].
PIAS4 interacts with the tumour suppressor von Hippel-Lindau (VHL) and leads to VHL sumoylation, oligomerization, and impaired function.
Both form and function have been impaired.
Consider both appearance and function.
We also established that the NTE domain plays an important structural and functional role: it is essential for HMT-1 oligomerization and Cd-detoxification function.
We demonstrated that the intra- and intermolecular domain interplay between the BSE and stalk was essential for oligomerization and the antiviral function of MxA.
Taken together these results indicate that NQTrp reduced both Aβ oligomerization and accumulation in AD model flies.
These mutations both inhibited oligomerization and restored activity to the fusion protein.
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