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Additional events during his STICU stay included delirium and dysphagia, both of which resolved.
Topical azithromycin dramatically improved ocular redness (reported by the patient) and bulbar conjunctival hyperemia (assessed by the ophthalmologist), both of which resolved within 1 month in all eyes (Figure 1A).
AKTi-1/2 treatment of mice at a dose of 100 mg/kg caused transient hyperglycemia that peaked 2 hours after drug administration and that was associated with a transient hyperinsulinemia, both of which resolved by 6 8 hours (manuscript in preparation).
Two cases of intussusception were recorded during the current study (one in each group), both of which resolved.
Twelve patients experienced serious adverse events (SAEs), but only three SAEs were related to study medication (Supplementary Table 1): grade 3 gastrointestinal inflammation and grade 2 anaemia (one patient), both of which resolved ad integrum, and persistent grade 4 neutropenia, for which the outcome could not be assessed (patient was lost to follow-up).
The second patient was a 58-year-old woman with metastatic breast cancer who was receiving bosutinib 400 mg per day plus capecitabine 1000 mg m−2 twice daily who experienced grade 3 increased alanine aminotransferase (ALT) and pruritus/rash, both of which resolved following temporary discontinuation of bosutinib.
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There were bouts of pain, oedema and reactive depression, all of which resolved after completion of treatment.
Most common adverse events (>5%) were pain at the site of injection and muscular weakness, all of which resolved without sequelae.
Over the subsequent 4 months, the patient experienced three vitreous hemorrhages in the right eye and two in the left, all of which resolved with observation.
There were three other withdrawals because of adverse events, two with CDA (vomiting and febrile convulsion) and one with AL (hematuria), all of which resolved.
Three SAEs were reported, all of which resolved.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com