Sentence examples for both of which modulate from inspiring English sources

DAT is acutely regulated by protein kinase C (PKC) activation and amphetamine exposure, both of which modulate DAT surface expression by endocytic trafficking.

This evidence is also supported by functional data of genetic ablation or pharmacological inhibition of TRPV4, both of which modulate thermogenic and proinflammatory pathways in adipose tissue (108).

Ra has also been shown to induce the regulation of the phosphatidic acid precursors, phospholipase C PLCC) and phospholipase D (PLD), both of which modulate the PCD as lipid-based signals.

Important mediators of cross talk between cytoplasmic and nuclear steroid receptor signaling are the proline-, glutamic acid-, and leucine-rich protein-1 and paxillin proteins, both of which modulate membrane and nuclear receptor pool signaling to promote a variety of cell biological functions.

Vitamin D receptor knock-out mice experience a marked increase in renin expression, plasma Ang II production, and hypertension [ 33], while, in adequate levels, 25-hydroxyvitamin D inhibits macrophage stimulation [ 34] and suppresses endothelin-induced vascular smooth muscle cell proliferation [ 35], both of which modulate endothelial cell function and arterial stiffness.

30 31 Emotional stressors such as PTSD may enhance progression to HIV through several pathways such as central nervous system activation of the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system, both of which modulate the release of hormones which can lead to qualitative and quantitative changes in immune functioning.

Importantly, the large majority of GWAS-associated loci involve noncoding variation, many of which modulate levels of gene expression.

Many different pathways have been described, all of which modulate synaptic function.

Interestingly, in all tested patients a total of 23 genes were commonly modified some of which modulate immune responses.

The modification occurs on nuclear and cytosolic proteins, many of which modulate cell signaling (Hanover et al. 2010; Slawson et al. 2010).

This effect could be due to differences in the pathophysiology of CAD in diabetics, as has been observed at the plaque composition level, [ 21] or due to diabetic medications, some of which modulate gene expression and affect cardiovascular disease [ 22].