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Interleukin-1 consists of two molecular species, IL-1α and IL-1β, both of which exert similar biological functions through the IL-1 type I receptor [ 52].
Recent studies have identified another two deubiquitinating enzymes, USP19 and USP24, both of which exert negative control on autophagy under normal nutritional conditions [ 270].
IL-1 is a prototypic pro-inflammatory cytokine that exists in two forms, IL-1α and IL-1β, both of which exert similar but not completely overlapping biological functions mediated through the IL-1 receptor (IL-1R).
Finally, it should be noted that the results of recent studies indicating that supplementation with branched-chain amino acids and acyclic retinoid, both of which exert chemopreventive effects on the development of HCC in clinical trials [ 3, 42], suppresses DEN-induced liver tumorigenesis in db/db mice by improving hepatic steatosis and attenuating chronic inflammation [ 22, 43].
When food reaches the intestine, L- and K-cells in the distal small bowel are stimulated to produce glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), respectively, both of which exert their effects on different targets (11).
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Unlike AT&T and Microsoft, both of which exerted a strong technological "lock in" over their customers, Google operates in a more open market that is easier for competitors to contest.
We all have our religions, all of which exert a special pull — and draw special fervor — when apprehension runs high and confusion deep, as they do now.
I certainly would not have tried to get a glimpse by visiting his home at Alnwick Castle, the monstrous requirements of which exert a malign influence on the town and countryside around it.
ABC transporters comprise various efflux proteins, some of which exert abnormal responses to exogenous compounds due to the presence of polymorphs.
In surface-water dominated hard rock regions, modern ground and surface water monitoring programmes often have very high resolution chemical, meteorological and hydrological observations but lack an equivalent emphasis on the subsurface environment, the properties of which exert a strong control on flow pathways and interactions with surface waters.
These are implemented by a cellular network that connects thousands of molecules, many of which exert a regulatory role in a multiplicity of biological contexts.
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