Consistent with activity as an Arf regulator, the Arf GAPs affect both of these pathways.
In human medulloblastomas reverse transcription-PCR for Shh and Notch targets revealed activation of both of these pathways in most tumors when compared with normal cerebellum.
Interestingly, while plausible structural models could be generated for states along both of these pathways, energies for species along the mono-zinc pathway were consistently lower than those obtained for the di-zinc mechanism.
Both of these pathways are involved in phagocytosis, the trash-collection process by which specialized cells in the body engulf, ingest and digest dead cells; foreign materials, including bacteria; debris from wounds; and so forth.
In a habituated brain, both of these pathways were stronger, but interestingly, the "go" signal got a head start it activated more quickly than the stop signal.
TAK1 affects both canonical and non-canonical BMP signal transduction and we found that both of these pathways contribute to BMP2-mediated Sox9 promoter activation.
The pectin-specific cluster which we identified contains genes related to both of these pathways, as well as for transporting pectin.
The IR/DR certificate can be attained via one of two pathways, the Integrated IR Residency, and the Independent IR Residency; residency programs can apply for either or both of these pathways.
It is time to get to work - together and aggressively - to pursue both of these pathways to a future bright with corals.
"[T]here are two pathways by which the body detoxifies harmful substances and it's essential to support both of these pathways in order to detoxify effectively," says Dr. Nieske Zabriskie.
