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Both of these cell lines were developed from mouse tissues.
Both of these cell types are notable for their ability to cause immunosuppressive conditions and support the evasion of tumour immune surveillance.
Stable transfectants of both of these cell lines that constitutively express 10- to 30-fold higher cell surface levels of CEA/CEACAM6 than endogenous levels failed to polarize and differentiate into glandular structures in monolayer or 31) culture or to form colonic crypts in a tissue architecture assay in nude mice.
In both of these cell lines, telomeres do not shorten with increased passage number.
Both of these cell types originate from epithelial progenitors that become specified as prosensory precursors.
Both of these cell types create stiffness gradients that persist beyond their periphery.
Both of these cell lines are deficient in the TLR3 PRR axis but support hantavirus replication [3], [34], [36], [37].
Both of these cell types generally assist in the clearance of bacterial pathogens from the lungs of mice and humans [50], [51].
The results presented in Fig. 1B, suggest that both of these cell lines displayed no reduction in viral RNA following IFN-γ treatment.
Although both of these cell lines can form primary tumors, intravasate, survive in the circulation and extravasate into the lungs, only the 4T1 cells form macroscopic metastases.
To determine if the proliferative effect in both of these cell lines was specifically due to CXCL8 treatment, a CXCR2 neutralising approach was undertaken.
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