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Cytogenetic studies have revealed that most MFHs have complex karyotypes with numerous aberrations, both numerical and structural.
Cr VI) exposure has been shown to induce chromosome instability, including both numerical and structural aberrations, which might cause similar expression changes in multiple genes clustered in a chromosomal region.
Apart from whole-chromosomal gains, Pim-1 polyploid cells exhibited a wide range of both numerical and structural aberrations including chromosomal translocations and deletions (Figures 3B, C), whereas control Neo and Pim-1 diploid cells had fewer structural abnormalities and numerical variations.
However, SINEG2 keratinocytes showed both numerical and structural chromosome aberrations.
MM is characterized by profound genomic instability involving both numerical and structural chromosomal aberrations of potential prognostic relevance [ 1, 2].
Because of a complexity of karyotypes and a highly unstable genome, OS usually exhibits both numerical and structural chromosomal alterations [ 2].
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Among the abnormalities, 85 blastocysts had numerical chromosome aberrations, 127 contained imbalanced structural aberrations, and 44 blastocysts were detected with both numerical and imbalanced structural aberrations.
Of the 1,058 blastocysts with SNP array analysis, 468 (44.2%) euploid and 590 (55.8%) chromosomally abnormal blastocysts were identified, 189 blastocysts had numerical chromosome aberrations, 298 contained imbalanced structural aberrations and 103 blastocysts were detected with both numerical and imbalanced structural aberrations.
Osteosarcoma is an extremely genomically unstable tumor, with karyotypes harboring numerous numerical and structural changes [ 7, 8].
In both cases, conventional cytogenetic techniques revealed complex numerical and structural chromosomal abnormalities.
HL is a malignant proliferation of lymphoid cells that frequently exhibits CIN and extensive cytogenetic analyses have routinely identified numerical (and structural) changes in chromosomes within both HL patient samples and cell lines [ 29- 31].
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both economic and structural
both decorative and structural
both behavioral and structural
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both functional and structural
both numerical and mass
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both hydrodynamic and structural
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both aerodynamic and structural
both geometrical and structural
both numerical and physical
both numerical and approximate
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