In the liver, 5-HT appears to mainly promote constriction of hepatic sinusoids, since mice lacking peripheral serotonin (Tph−/−) display enhanced sinusoidal perfusion under both normal and diseased states [10].
Both normal and off-normal process scenarios are modeled.
Both normal and off-normal loading conditions have been analyzed.
This works in both normal and hardcore.
Thus, in some circumstances tumours are able to 'parasitize' the normal stroma and sinusoidal vasculature for its metabolic needs.
Occult metastases were parenchymal in 25, sinusoidal in 27, both parenchymal and sinusoidal in seven, and separate deposits were seen in the peripheral sinus and the capsule in one node.
These events culminate in nuclear and cytoplasmic swelling, cytoplasmic vacuolization, and mitochondrial swelling of both hepatocytes and sinusoidal endothelial cells that finally cause apoptosis [ 44].
Both the canalicular and sinusoidal surfaces have distinct cytochemical, immunological and biochemical characteristics that are crucial for maintaining normal hepatic function (Roman and Hubbard, 1983; Hubbard et al., 1985; Maurice et al., 1985; Stevenson et al., 1986; Chapman and Eddy, 1989).
Recent results suggest that the resistance is primarily in the sinusoids and is distributed relatively uniformly along the sinusoidal length both in normal and cirrhotic conditions [ 40- 42].
Particularly, unlike cosine-curve-based algorithms, ARSER can identify both non-sinusoidal and sinusoidal patterns.
