Here, we report a novel mechanism linking IGF1-IGF1R and KITLG-KIT signaling in both normal and neoplastic cells.
The transcription factor nuclear factor-κB (NF-κB) is a central mediator of growth and homeostasis for both normal and neoplastic cells.
Furthermore, uridine plays a role at the clinical level in modulating the cytotoxic effects of fluoropyrimidines in both normal and neoplastic tissues.
The purpose of this study was to further define the distribution of MSI in both normal and neoplastic thyroid follicular epithelium.
In this Opinion article, we explore the role of programmed cell removal in both normal and neoplastic cells, and we place this pathway in the context of the initiation of programmed cell death.
Together, these studies establish a key role for p53 in the cellular response to telomere dysfunction in both normal and neoplastic cells, question the significance of crisis as a tumor suppressor mechanism, and identify a biologically relevant stage of advanced crisis, termed genetic catastrophe.
We hypothesize that GRP gene expression may play a role in both normal and neoplastic growth processes.
α-Interferon is capable of altering the pattern of growth of both normal and neoplastic cells, but the pathways essential to sensitivity and resistance to α-interferon are unknown.
Since those seminal discoveries, more groups have examined the expression patterns of MELK using different organ systems and cell types, and across different species in both normal and neoplastic cells.
The 65 kDa isoform is expressed in both normal and neoplastic ductal epithelial cells.
No role for ERα has been demonstrated in the regulation of PCNA gene expression although estrogens act as potent mitogens in both normal and neoplastic breast and uterine tissues.
