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In the study, base editing sometimes repaired only one faulty gene rather than both, creating so-called mosaic embryos that had both normal and mutant cells.
Understanding anatomical aspects of mammalian organ development, in both normal and mutant animals, is important for basic biology and also for regenerative medicine and tissue engineering.
Furthermore, combining these reporters with the study of mouse mutants will be a step forward in understanding the inter- and intracellular behaviors underlying morphogenesis in both normal and mutant contexts.
Severity and even penetrance can vary widely for disorders resulting from mutations in the mitochondrial DNA, generally believed to reflect the combined effects of heteroplasmy (i.e., mixed populations of both normal and mutant mitochondrial DNA in a single cell) and other confounding genetic or environmental factors.
Next, using 10 mice genetically engineered to lack both normal and mutant GRIP proteins, researchers watched what happened when each animal was put into a box where it could choose between spending time with a mouse it hadn't encountered before or with an inanimate object.
Suspecting that VNO might help the rodents sniff out predators as well, neurobiologist Lisa Stowers of The Scripps Research Institute in San Diego, California, dropped cotton balls laced with either cat saliva, rat urine, or snake skin essence into the cages of both normal and mutant mice with inactive VNOs.
Similar(39)
The other chromosomes are free to drift genetically in both normal and smn mutant strains.
These primers annealed to both the normal and mutant OCPs.
The generic P2 was not part of the target specific portion of the probe, which allowed it to be used in both the normal and mutant OCP.
This quantifiable characteristic of the recombinant A-domain therefore allowed us to study the disulfide bonded ("folded") state of both the normal and mutant A-domains in greater detail.
Interestingly, work in the roundworm C. elegans has shown that the expression of both normal and FTDP-17t mutant tau results in neurodegeneration and defective neurotransmission but that the pathology is more severe in the latter [ 29].
More suggestions(15)
both normal and thrombocytopenic
both normal and diseased
both normal and useful
both normal and cancerous
both normal and reversed
both normal and plug-in
both normal and psoriatic
both normal and contingent
both normal and vitamin-depleted
both active and mutant
both normal and damaged
both normal and fast
both normal and shear
both normal and constant
both wildtype and mutant
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