The knowledge that let-7 suppresses both normal and malignant growth will have particular relevance to malignancies that arise from chronically injured tissues.
It is directed against the CD20 antigen present on the surfaces of both normal and malignant B lymphocytes.
Conclusion: Adrenomedullin may be involved in both normal and malignant tissue growth through both vascular and growth factor effects.
Surprisingly, little is known about the influence of Th cells on both normal and malignant precursor B cells in the bone marrow.
Context: The insulin-like growth factor (IGF) system exerts many effects on the growth and differentiation of both normal and malignant cells.
Conventionally, both normal and malignant breast cells are studied in vitro as two-dimensional monolayers of epithelial cells, which results in the loss of structure and tissue function.
Previous expression studies of AQP5 in human tissues, both normal and malignant, have been only in epithelial tissues and carcinomas.
This distribution is conserved across different tissues, both normal and malignant, as well as evolutionarily across divergent species [2], [3].
Thus, PDK1 appears to have diverse roles in both normal and malignant cells through kinase-dependent and -independent mechanisms.
We conclude that different stress signals, including inflammation, atrophy and androgen ablation upregulate AhR expression in both normal and malignant prostate cells and conduct a protective mechanism.
Enumerating this population and quantifying the effect(s) of treatment is difficult as stem cells (both normal and malignant) are defined by function.
