Sentence examples for both normal and leukemic from inspiring English sources

Our study demonstrates highly distinctive cytokine responses in STAT5 phosphorylation in both normal and leukemic stem/progenitor cells.

For example, Bmi-1, a polycomb group (PcG) gene, was shown to be essential for both normal and leukemic mouse SC proliferation [9].

These pathways (which include PI3K/Akt, Ras/Raf/MAPK, and Jak/Stat) play important roles in proliferation, survival, cell cycle progression, and differentiation in both normal and leukemic hematopoietic cells [54].

IL-15 appears to play a major role in the hematopoietic development controlling the survival, proliferation, and differentiation of both normal and leukemic progenitors, and can promote pathogenesis of leukemic cells [21] [25].

During normal T-cell development, Tcra−/− Relb−/− thymi presented a slight reduction in thymocyte cellularity as compared to Tcra−/− Relb+/− thymi, suggesting that both normal and leukemic T cell expansion is affected by RelB-dependent thymic stroma.

In conclusion, we find that intracellular FACS analysis is an informative tool to study cytokine-induced STAT5 phosphorylation at a single-cell level, in both normal and leukemic stem/progenitor cells.

Using adoptive transfers of human cells into immune-deficient mice, VLA-4 was identified as a key molecule for both the bone marrow homing and the engraftment of normal and leukemic human HSPCs [ 71, 72].

These observations warrant further investigation using normal and leukemic primary cell models.

Signal Transducer and Activator of Transcription 5 (STAT5) plays critical roles in normal and leukemic hematopoiesis.

Our current study reveals highly distinct cytokine responses in normal and leukemic stem and progenitor subpopulations.

For instance, Stat transcription factors are known to play a critical role in normal and leukemic hematopoiesis targeting transcription of genes involved in proliferation, survival and differentiation [51] [54].