Sentence examples for both normal and hypoxic from inspiring English sources
The key finding is that flunarizine can alleviate cerebral mitochondrial injury under both normal and hypoxic conditions, a not unexpected effect attributed likely to blockade of voltage-gated calcium channels.
Our model contains three tumor-cell types: normal, hypoxic and necrotic (we use the designation tumor cell to refer to both normal and hypoxic cells).
To delineate the effect of H19 levels on p57kip2 levels, we knocked-down H19 levels with siRNA H19 #3 in the Hep3B cell line, and siRNA H19 #1 in UMUC3 under both normal and hypoxic conditions.
PC12 extracts were obtained from both normal and hypoxic cells (lanes 1 2).
Most importantly, VE-821 increased radiation-induced loss of viability in both normal and hypoxic conditions.
Moreover, experimental data showed that the AT1 receptor was the predominant subtype in both normal and hypoxic lungs [ 11] and that the pulmonary vasotonic response to angiotensin II was mainly due the AT1 subtype [ 36].
Therefore, we examined the proliferative potential of fibroblasts derived from MCT animals and compared them to that of fibroblasts isolated from both normal and chronic hypoxic animals (Fig. 1 A ).
Although miR-210 was reported to be upregulated in both normal and transformed hypoxic cells [ 3, 6, 12], mouse models of brain transient focal ischaemia [ 4] and cardiac hypertrophy/cardiac failure, and in placentas from patients with preeclampsia, our data showed that miR-210 expression was downregulated in the brain 72 h after HI injury than in normal control.
Here we addressed the metabolic consequences of indomethacin treatment on two AML cell lines under both normal and arguably more realistic hypoxic conditions.
These studies were performed using both monolayer cell cultures, in normal and hypoxic conditions, and PDAC cells growing as spheroids.
miR-210 is the only miRNA so far identified which strongly responds to hypoxic stress in virtually all experimental systems in vivo and in vitro and in both normal and tumour cells under physiological hypoxic conditions [ 91].
