To address this new area of biology, graduate student Erika Gruber, D.V.M. '06, took advantage of techniques in biomedical engineering to grow macrophages on finely tuned engineered surfaces that approximate human tissues from both normal and diseases states.
HHV-6 has also been detected in CD34+ progenitor cells in both normal and diseases states [48], [49].
The Raman spectra of both normal and disease populations are shown in Fig. 1 (normalized to CH2 bending mode of proteins and lipids at 1443 cm−1, as described below).
Overall, we anticipate that these efforts will lead to new mechanistic insights into how the genome is organized, maintained, expressed and replicated, in both normal and disease states.
The primary focus of the Rodeheffer laboratory is to elucidate the cellular and molecular mechanisms that control adipose tissue mass in both normal and disease states.
Without such a "parts list," it will be difficult to understand how individual neurons in a brain circuit ultimately contribute to behavior, in both normal and disease states.
Determining modifier genes is extremely important for understanding differences in both normal and disease phenotypes, and for designing potential therapeutic avenues for disease.
These techniques, together with gene expression profiling, are useful for analyzing epigenomic regulation of cell specification, differentiation, and function during zebrafish development in both normal and disease models.
Neuroimaging enables us to delineate the structural and functional organization of the brain, which is key in understanding how the neural system functions in both normal and disease states.
In this review, we detail the structures of methyllysine binding domains, highlight the primary roles of these reader proteins in both normal and disease states, and describe the current status of small molecule development against these emerging epigenetic regulators.
The rapid ability of multicellular tissues to physically remodel their matrix enables their constituent cells to migrate efficiently along aligned fibers and to quickly change their direction according to other microenvironmental cues, which is important for both normal and disease processes.
