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In both normal and benign breast disease the staining was largely extracellular whilst in malignant tissue the staining was variable and often intracellular.
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In contrast, WT1 protein was not detected in both normal prostate and benign prostatic hyperplasia samples.
Based on the expression of VEGF-C of the epithelial component, both normal gland and benign tumours produced similar results, for example regarding the comparison between intratumoral (intramammary) and extratumoral (extramammary) fields.
The subtracted library of cDNAs down-regulated in the MCF-7 cells relative to the Huma 123 cells contained a cDNA corresponding to the mRNA for an EF-hand protein, S100A2, which was shown previously to be abundantly expressed in both normal breast and benign breast tumour specimens (Liu et al, 2000), but only detectable in less than 15% of malignant breast cancer specimens tested.
However, in terms of discrepant recall decisions between individuals and overall decisions, there were both over-reading (for the normal and benign cases) and under-reading errors (for the malignant cases) for many cases; although there was no statistical difference in the error rate between these three case categories.
Normal and benign nodes tend to show central hilar vascularity and central symmetric vascularity.
KLK6 protein was expressed at low levels in normal and benign ovarian tissues.
These disease-related features can be used to distinguish cancer lesions from normal and benign tissues.
Our signature was trained on a high number of controls, and upon validation showed a remarkable specificity both on normal subjects and benign lung nodules.
We included both normal ovarian tissue and benign tumor samples for comparison with LMP and invasive serous tumors.
RARβ is significantly decreased in breast cancer (0.8 0.04) log RQ) compared to both normal (1.3 0.09 log RQ) and benign (1.5 0.07)log RQ) p < 0.001 tissue.
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CEO of Professional Science Editing for Scientists @ prosciediting.com