Sentence examples for both normal and arthritic from inspiring English sources

Indomethacin produced intestinal lesions in both normal and arthritic rats, but in the latter, the ulcerogenic response occurred much earlier and the severity was markedly enhanced.

In addition, some positive chondrocytes were observed in both normal and arthritic joints.

The levels of biochemical markers of oxidative stress, that is, nitric oxide (NO) and peroxide (PO) were determined in the plasma samples of both normal and arthritic groups.

Furthermore, there was evidence of significant fragmentation of SLRPs in both normal and arthritic tissue, with specific catabolites of biglycan and fibromodulin identified only in the cartilage from meniscectomized joints.

Moreover, we showed that sites of cleavage of Col II by collagenases are usually co-localized with sites where the cathepsin K cleavage neoepitope is also found, suggesting that different proteases are active in sites of Col II cleavage in both normal and arthritic cartilages.

In addition, the bands from both normal and arthritic homogenates incubated in the presence of the TG2-specific inhibitor Z-DON showed reduced intensity compared with vehicle, whereas a stronger reduction was obtained by using the TGs inhibitor KCC-009 (see Additional file 2, Figure S2A).

To investigate the functional contribution of glial cells in the spinal cord nociceptive transmission, the effect of intrathecally administered IL-1β was studied in both normal and adjuvant-induced arthritic rats with or without glial inhibition.

Fibronectin, an ECM glycoprotein, and fibronectin fragments have been associated with enhanced levels of catabolic cytokines and up regulation of MMPs involved in both normal homeostasis and arthritic diseases.

Aminoguanidine, an inhibitor of iNOS, significantly suppressed the damage, yet the efficacy differed in normal and arthritic rats, depending on the dose schedule; the effect of post-administration (6 h after) was greater than that of pre-administration (0.5 h before) in normal rats, whereas that of post-administration was less than that of pre-administration in arthritic rats.

To aid in detection of osteoarthritis (OA) progression in serial magnetic resonance (MR) scans, we assessed feasibility and accuracy of rapid 3D image registration of the tibial plateau in normal and arthritic subjects, and inter-scan reliability of semi-automated cartilage volume measurement from these images.

The aim of this study was to characterize the expression of BMPs in synovial tissues under normal and arthritic conditions.