Sentence examples for both normal and aberrant from inspiring English sources

Defining the mechanisms that govern these events is of great interest; such information could be used for therapeutic benefit as well as to increase the current understanding of HSC self-renewal in both normal and aberrant hematopoiesis.

The integrated genome-scale analysis applied in this study represents a valuable and widely applicable approach to study the transcriptional control of both normal and aberrant haematopoiesis and to identify critical factors responsible for transcriptional reprogramming in human cancer.

Our re-examination of how aberrant chromosome configurations behave in female meiosis has provided several insights into prometaphase I chromosome movements of both normal and aberrant chromosomes.

Spy1 can prevent the inhibitory effects of the tumor suppressor p27Kip1 on Cdk2 by directly promoting p27 degradation, suggesting yet another mechanism by which Spy1 can enhance both normal and aberrant cell growth [ 3- 5].

Taken together, it is apparent that tipping of any regulatory components will have profound effects on A-to-I editing, which in turn contributes to both normal and aberrant physiological conditions.

Therefore, it is important to better define the function of histone modifications and the interplay among the enzymatic activities (COMPASS-like, hBRE1, PAF1 complex, USP22, and so on) that promote these modifications if we are to fully understand how chromatin contributes to both normal and aberrant activated transcription in mammalian systems.

The majority of DTA-1-treated tumor sections contained only the aberrant Tregs; however, some sections contained both normal (foxp3+) and aberrant (foxp3-) GFP+ cells (Figure 6F), demonstrating that this was not a staining artifact.

As an important oncogene, Ras plays important roles in both normal development and aberrant biological processes, such as tumorigenesis and developmental disorders [ 25].

Both normal vessels and aberrant structures induced by all VEGF doses were stained by lectin and therefore functionally perfused (Fig EV1A).

This regulation can influence both normal genes and aberrant ones, affecting the likelihood of disease.

They allow for both the study of normal and aberrant gene interactions in tumors and the recapitulation of human disease in mice, providing a key resource for studies of chemoprevention and for development and testing of novel cancer therapeutics.