These cultures contained both neuronal and non-neuronal (glial) cells.
Advances in neuroscience require better anatomical knowledge of neuronal architecture and structural details.
There have been recent attempts at explaining neuronal position and structural layout of the network by using static constraints, such as wiring economy and communication path minimization.
Decreased ERK activation as we observed in mutants might ensure neuronal resistance and structural plasticity, thereby facilitating cell integration.
Surprisingly, both functional and structural neuronal damage evolved after the inciting trigger was no longer present, and persisted for at least 2 months after the BBB breach.
Because of its relatively simple anatomic architecture, the peripheral ANS serves as a model system to understand neuronal development, structural and functional linkages among neurons and their targets, and the integrative role(s) these "little brains" (6,000 30,000 neurons) serve.
Emerging evidence suggests that activity‐regulated proteolysis at neuronal synapses mediates synaptic strength and structural remodeling of neuronal circuits.
Neurite swellings, thought to be the residues of aberrant intra-ganglionic sprouting, may be axonal or dendritic in nature, and have been described as being large accumulations of small mitochondria and neuronal structural proteins [ 18, 46, 47, 51].
Therefore, it is important to compare the parallel behaviour of the organization of functional and structural neuronal anatomy in the brain, and the complex networks of graph theory.
