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The two characters are both mutants, but they occupy opposing political extremes.
Both mutants retained the global structure of the native protein (Fig. S2e).
After 48 h in synthetic wounds, (Figure 5), both mutants had a relative fitness of 1 regardless of culture condition.
Matte and I were both mutants, freaks, human unhumans — a fact I could at least forget when I was with real people, those with death in them".
To understand these effects, we have crystallised both mutants and solved their structures.
The prevalence of both mutants decreased at the end of the two-week follow-up period.
However, both mutants are defective for recruiting FANCM to Flex1 and for suppressing Flex1-induced mitotic recombination (Fig. 2f, right, 2g, and Supplementary Fig. 5g).
We found that both mutants exhibited clear motility defects as evidenced by a reduced average speed of individual worms compared to wild type (Fig. 2d, Supplementary Fig. 2a).
After 48 h (Figure 4b), there was no difference between genotypes or culture conditions: both mutants had a relative fitness of 1 regardless of wild-type presence.
By contrast, there was an increase in fluorescence when an equimolar mixture of both mutants was tested, indicating that CaM bridges the two proteins41 (see supplemental Fig. 6D).
Both mutants have an enlarged active site that accommodates the new substrates while retaining the high stereo- and regioselectivity of the wild-type enzyme.
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CEO of Professional Science Editing for Scientists @ prosciediting.com