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Selective elimination of Cr-DNA adducts from Cr VI -treated plasmids abolished all genotoxiCr VI -treatedndicating that nonoxidative, Cr(III)-deplasmidsreabolishedere responsible for the induction of both mutallnicity and replication blockagenotoxicVI).
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Standard mutagenicity assays in preincubation tests were performed for both mutagenicity and antimutagenicity assays [ 22].
Thus, both the mutagenicity and binding of DMP are inversely related to the metabolism of this compound.
Yet, they do not simultaneously accommodate for both isolation and replication.
40345_2017_101_MOESM1_ESM.docx Additional file 1. Detailed prediction results in both discovery and replication cohorts.
Both structural and replication genes are not clustered in CP21.
(27) Blocking of Cr-DNA binding during the reduction or dissociation of Cr-DNA adducts eliminated all mutagenic and replication-blocking responses in shuttle-vector plasmids incubated in Cr VI) reactions containing Asc, GSH, 38) or Cys, 37) demonstrating a key role of Cr-DNA adducts in the mutagenicity and genotoxicity of Cr VI) when metabolized by its three main biological reducers.
DTE was dissolved in DMSO and different concentrations of DTE (1, 10, 100, 500, 1000 μg/plate) were used in both mutagenicity assay and antimutagenicity assay against known mutagen B[a]P.
The NPAHexposed /NPAHunexposed profiles, from both the mutagenicity and chemical studies, showed the formation of 1-NP and 6-NBaP from OH radical exposure.
Coincubation of isolated, intact rat hepatocytes with Salmonella typhimurium tester strain TA 98 (Salmonella/hepatocyte system) has been employed to determine both bacterial mutagenicity and DNA damage in the hepatocytes following treatment with 2-acetylaminofluorene (AAF) and other AAF derivatives.
Rif1 loss affects both number and replication-timing specificity of the interactions between replication-timing domains.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com