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pI 5.9 and 6.3 forms are detected in both mouse types and in both conditions.
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To address this issue, we subjected both the wild type and CC10-Smad7 mice to urethane treatment.
Although autoantibody production and glomerulonephritis are abolished in interferon receptor (IFNAR -/- mIFNAR -/- wild-type and IFNAR-/- mice developed anemia and bothypocellularity following pristane treatment.
Finally, huE6F6 Fc mutant M252Y/S254T/T256E (huE6F6-YTE) showed considerably longer serum half-life than the wild-type antibody in both mouse and cynomolgus monkey models.
In contrast, ELISA revealed a dramatic increase of circulating levels of transgenic IL-6 in mdx/IL6 mice, compared with both wild-type and mdx mice (Fig. 2B).
Cells were injected into C57BL/6N blastocysts to generate chimera animals that were further backcrossed twice with C57Bl/6N mice to generate both, wild-type and RasGrf1−/− mice.
Furthermore, we investigated the in vivo impact of oral L-phe challenge on aortic and systemic biopterin and BH4 levels in both wild-type mice and in mice lacking endothelial GCH1 [GCH1(fl/fl)-Tie2Cre] (Chuaiphichai et al., 2014).
More recently, when type A and type B strains were compared using aerosol, intradermal, and intravenous routes of infection in both BALB/c and C57BL/6 mice, type A infected mice succumbed to infection approximately one day earlier than mice infected with type B [16].
Mutant mice expressed both wild-type and mutant decorin.
This has been elegantly demonstrated in mice by the breeding of mice transgenic for mutant p53 (Val135) to both wild-type and Trp53-/ mice.
Conversely, transgenic overexpression of GPR40 results in mice improved glucose-stimulated insulin secretion in both wild-type and diabetic mice (24).
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