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To investigate whether proteasomal inhibition by organotins is associated with cell death induction, we investigated both morphologic changes and PARP cleavage.
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The cultures were observed daily for morphologic changes and harvested 3 days after inoculation.
We observed morphologic changes and depolarization in mitochondria by MitoTracker and JC-1 staining.
In addition to these morphologic changes and their consequences, predictable biochemical and oxidative changes occur over prolonged storage.
We sought to characterize morphologic changes and the role of oxidative stress within the ICNS of diabetic hearts.
Knockdown of MYB in PMC42-LA cells (MYBsh-LA) led to morphologic changes and protein expression consistent with an EMT.
However, the morphologic change and expression of synaptophysin and chromogranin was not evident in these patients.
Both biochemical and morphologic changes in brain regions that are linked to cognitive and motor performance have been reported after dietary exposure to As in animal studies (Dhar et al. 2007; Haider and Najar 2008; Mishra and Flora 2008; Rao and Avani 2004; Samuel et al. 2005; Wang Y et al. 2009).
Of note, 84.6% of embryos injected with half concentration of exon 9 morpholino exhibited the same phenotypic (both motor and morphologic) changes (n = 78, data not shown).
Two major morphologic changes take place and contribute to the development and enlargement of the fat depot in mice.
Histologic analysis of effects of both E2 doses revealed well-known morphologic changes in uterus (Cummings and Yochim 1984; Fazleabas and Strakova 2002).
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