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There is increasing evidence supporting the role of rare variants in both monogenic and complex diseases [1] [6].
Disease-association studies, both candidate gene-based and genome-wide association studies (GWAS), have identified genetic variants that associate with both monogenic and complex diseases like lung cancer.
Different combinations of such variants may contribute to the variable penetrance characteristic of both monogenic and complex disease.
Related questions are also likely to arise in basic research projects on both monogenic and complex (i.e. oliogenetic) diseases.
CNV have been linked to the pathogenesis of both monogenic and complex disorders [ 7- 13] including brain-related disorders such as schizophrenia [ 14- 17].
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Our idea is to transform a RHBVP with variable coefficients for monogenic functions with axial symmetry in (mathbb{R}^{4}) into a RHBVP for analytic functions over the complex plane, use the classic results from complex analysis, and transfer it back.
For AD and PD, both familial (monogenic and complex inheritance) and sporadic forms exist while some like HD are purely genetic in nature.
Daetwyler, H. D. et al. Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle.
They have also been linked to some monogenic and complex human diseases [ 3, 4].
When examined closely, the division between monogenic and complex traits quickly breaks down.
Our findings provide an example of the overlap in genetic determinants of monogenic and complex obesity.
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both vivid and complex
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both monogenic and full
both expensive and complex
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both primitive and complex
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both isolated and complex
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both monogenic and dominant
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