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In both modes of binding, SSB can move along ssDNA using a rolling mechanism.
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We suggest that all syntaxin/SM pairs interact using both of these modes of binding at different stages of the SNARE assembly/disassembly cycle.
The flexible 1,25(OH)2D3 molecule was found to have a high affinity for both pockets, with differing modes of binding.
The results corroborate evidence for these binding interactions and indicate multiple high-affinity modes of binding.
We hypothesize that the multivalency of the involved molecules leads to different modes of binding.
These findings open up the possibility of designing compounds with new modes of binding.
Docking studies showed structural variations in their modes of binding which explains this unexpected observation.
These data have shown the great diversity of sizes, shapes, and modes of binding of the substrate binding sites of these mammalian cytochromes P450.
The resulted modes of binding from docking simulation show a good correlation with the experimentally determined hydrolysis pattern.
The three compounds affected very similar sets of cross peaks, indicating their similar modes of binding.
During recent years, a growing number of non-classical modes of binding for CaM towards its target peptides have been detected [1], [7] [11].
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