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Among the necessary future work is to identify the minimal C-terminal fragment that still retains both mitochondrial localization and rescue ability, and to optimize the delivery method.
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Desai, S. P., Bhatia, S. N., Toner, M. & Irimia, D. Mitochondrial localization and the persistent migration of epithelial cancer cells.
We found that hypertonia-associated mutation impairs Trak1 mitochondrial localization and its ability to facilitate mitochondrial tethering and fusion.
Open image in new window Figure 3 Impairment of Trak1 mitochondrial localization and function by hypertonia-linked mutation.
The results of cellular uptake, mitochondrial localization, and cytotoxicity showed the Cur/TPP-oHA-S-S-Cur micelles had CD44 receptor-targeting ability and mitochondrial targeting ability.
Thus, interventions that rescue mitochondrial function, mitochondrial localization, and associated defects may maintain synaptic plasticity and neurological function [57].
However, mutant forms of hANT4 protein were isolated that facilitated proper mitochondrial localization and complementation of AAC-deficient yeast.
Interestingly, the mitochondrial localization and accumulation of Mieap following IR was significantly impaired in these NIX-deficient cells (Figure 4B).
These observations clearly, and unexpectedly, show PXN expression affects mitochondrial localization and dynamics.
We found that the mutant Anxa6S13E exhibited enhanced mitochondrial localization and reduced interaction with cleaved Parp1.
The output of sub-cellular localization prediction programs regarding the localization to mitochondria is given with numbers between 0 (no mitochondrial localization) and 1 (high probability of mitochondrial localization).
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