Mitochondrial inheritance and cancer.
Because plastids are paternally inherited in Pinaceae (Neale and Sederoff, 1989), plastids potentially track pine pollen flow in contrast to maternal mitochondrial inheritance and biparental nuclear inheritance.
The authors observed an excellent AUROC score for mitochondrial inheritance, and speculate that the reason is that the mitochondrial genome is well studied.
Mitochondrial inheritance and dynamics in yeast are maintained by distinct mechanisms: the fission and fusion of mitochondria, the mitochondrial segregation from mother to daughter, and the maintenance of mitochondria [ 71].
The molecular mechanisms underlying DUI are still unknown; however, many structural and functional features of M and F mtDNAs were proposed as candidates for a role in mitochondrial inheritance and germ line establishment/differentiation (Ghiselli et al. 2013; Milani, Ghiselli, Guerra, et al. 2013; Zouros 2013).
We described the general features of eight mt genomes from unionoid bivalve species with the doubly uniparental mode of mitochondrial inheritance and highlighted several unusual characteristics of the M genomes, compared to their female-transmitted counterparts, e.g., the presence of M cox2e and a novel localization of trnH.
This would have ensured sustained close contacts between host cytoplasm and proto-mitochondria, increasing the probability of vertical proto-mitochondrial inheritance, and helping to exclude parasitic microbes.
Given the peculiar features of mitochondrial inheritance, genetics and physiology, how transmission of viable mtDNA through generations is achieved is object of debate.
Objective: To determine the patterns of mitochondrial inheritance in embryos, fetuses, and infants after ooplasmic transplantation using the technique of mitochondrial DNA (mtDNA) fingerprinting.
