Of the 894 genes selected earlier, we chose to analyze only 798 gene products for which quantification ratios from at least four out of eight time points could be determined from both microarray and proteomic experiments.
Rapamycin has been shown to be a potent repressor of translation; both microarray and proteomic analyses have demonstrated that rapamycin significantly decreases translation of mRNA-encoding initiation factors and ribosomal proteins (Grolleau et al., 2002; Guertin et al., 2006).
Although several studies demonstrated the presence of moderate to poor correlations between microarray and proteomic analyses [13], [14], [15], [16], implementing both methods may generate complementary and more informative data that cannot be obtained by either method alone.
Genome-wide studies correlating drug response phenotypes with large DNA/tissue microarray and proteomic datasets have been performed to identify the genes and proteins involved in chemosensitivity or drug resistance.
At environmentally realistic exposure levels there could be "non-linear" dose-response curves, which should be accounted for in the experimental design and in the analyses of microarray and proteomic data.
We found a poor correlation between microarray and proteomic results.
CD34+ cells from BM, MPB, and UCB were fractionated into G0 and G1 phases of cell cycle and subjected in parallel to microarray and proteomic analyses.
Considering literature data, the biofilm phenotype of P. aeruginosa appears regulated more at the translational and perhaps post-translational levels than at the transcriptional level, as highlighted by the discrepancies between microarray and proteomic experiments.
Recently, microarray and proteomic analyses of human and mouse stem cells generated insights into the molecular composition of stem cell profiles [17], [18], [19], [20], [21], [22], [23], [24], [25].
Microarray and proteomic analyses revealed that PVL does not alter gene or protein expression, thereby demonstrating that any contribution of PVL to CA-MRSA pathogenesis is not mediated through interference of global gene regulatory networks.
Global microarray and proteomic analyses of Salmonella Typhimurium grown aboard the space shuttle mission STS-115 identified Hfq as the global regulator involved in the response to the space flight environment as well [29].
