Nonetheless, both methods gave comparable results when we compared the acetylation coverage between the CFS and NCFS sequences as described below (Supplementary Material, Fig. S3C).
Both methods gave comparable results.
In this study we calculated the costs of both methods (given comparable outcomes) and are the first to generate a differential cost-effectiveness analysis of both methods.
Methylation analysis was performed in the West Midlands Regional Molecular Genetics Laboratory using a methylation-sensitive multiplex ligation-dependent probe amplification (MS-MLPA) kit (SALSA MLPA kit ME030; MRC-Holland, Amsterdam, The Netherlands) and/or pyrosequencing, with both methods giving comparable results [ 10, 27].
Both MC and HSS methods give comparable results for the distribution of the response (Fig. 10).
The three methods give comparable results, indicating that motional factors which may affect the solid-state method are not significant.
As these methods give comparable results, in the tight periods of a consultation neurologists can use such simple and time efficient methods as pressure algometry and wind-up testing to detect the presence of CS.
The results presented highlight that the two methods give comparable sugar profiles, whether the samples analysed are simple raw materials, pigmented and unpigmented paint replicas, or paint samples collected from hundreds of centuries old polychrome art objects.
Similarly, for 38 genes where one method fails to show an absolute fold change >= 2 the actual fold change is just below 2 (cut off log2 fold change >= 0.8 or <= -0.8) suggesting further genes where the two methods give comparable fold change results.
